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1,2,4-Triazole

1H-1,2,4-Triazol; Pyrrodiazole; S-triazole

CAS 288-88-0

Chemical Formula C₂H₃N₃

Molecular Weight 69.07 g/mol

1,2,4-Triazole is an important nitrogen heterocyclic compounds which containing one of the significant heterocycles that exhibit broad biological activities, such as antimicrobial, analgesic, anti-inflammatory, anticonvulsant, antineoplastic, antimalarial, antiviral, antiproliferative, and anticancer activities. It has strong stability for thermal and acid condition; otherwise, it is insensitive to redox, hydrolysis, and enzymatic hydrolase.

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Industrial Uses

1. Pharmaceuticals

Heterocyclic Drug Intermediates: 1,2,4-Triazole is a five-membered heterocycle with three nitrogen atoms. It is widely used as a core scaffold in antifungal, antiviral, and anticancer drugs (e.g., fluconazole). Its structure provides stability, bioactivity, and hydrogen-bonding capability, enhancing drug-receptor interactions.
Antifungal Agent: 1,2,4-Triazole is a core structure in many antifungal drugs, such as fluconazole and itraconazole. It is used to treat fungal infections by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes.
Anticancer Agents: Some derivatives of 1,2,4-triazole exhibit potent anticancer activity and are being explored as potential chemotherapeutic agents. They work by inducing apoptosis in cancer cells or inhibiting specific enzymes involved in cancer cell proliferation.

2. Agrochemicals

Fungicides: 1,2,4-Triazole derivatives, such as tebuconazole, propiconazole, and triadimefon, are used as systemic fungicides in agriculture to protect crops from a variety of fungal diseases. These fungicides inhibit the synthesis of sterols necessary for fungal cell membrane development.
Plant Growth Regulators: Certain triazole compounds act as plant growth regulators, influencing plant growth and development. They can be used to improve crop yield, enhance resistance to environmental stress, and regulate flowering and fruiting.

3. Chemical Synthesis

Corrosion Inhibitors: 1,2,4-Triazole compounds are effective as corrosion inhibitors for metals such as copper and its alloys. They form a protective film on the metal surface, preventing oxidation and corrosion, particularly in cooling water systems and antifreeze formulations.
Polymer Stabilizers: Triazole derivatives are used as stabilizers in polymer production to enhance the thermal and UV stability of the final products, thus extending the longevity and performance of plastics and coatings.

4. Energy

Corrosion Protection: In the oil and gas industry, 1,2,4-Triazole is used in pipeline and refinery systems to protect against corrosion caused by harsh chemicals and gases. This helps maintain the integrity of pipes and tanks that are in contact with corrosive fluids.
Oil Recovery Processes: It can also be used in enhanced oil recovery methods, where it is involved in chemical processes to improve oil extraction from reservoirs.

5. Construction

Concrete Additives: In some formulations, 1,2,4-Triazole is used as an additive in concrete to improve its durability and protect it from chemical attack, especially in corrosive environments.

5. Water Treatment

Corrosion & Scale Inhibitors: Studies have demonstrated that 1,2,4-triazole and its derivatives can significantly inhibit the corrosion of carbon steel in acidic environments by forming thin, protective films on the metal surface. Copper Protection: 1,2,4-Triazole has been identified as an effective corrosion inhibitor for copper, offering comparable protection to benzotriazole in certain applications.

Specifications

Assay	≥ 98%
Appearance	Clear, colorless to pale yellow liquid
Odor	Amine-like odor
Boiling Point	184-186°C (363-367°F)
Melting Point	-70°C (-94°F)
Density	0.936 g/cm³ at 25°C
Solubility	Soluble in water, alcohol, and most organic solvents
Viscosity	1.27 mPa·s at 20°C
Flash Point	67°C (153°F) (closed cup)

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FAQs

1. What is the current price of 1,2,4-Triazole in India?
The price of 1,2,4-Triazole can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.979 979 2121 directly for a customized quote tailored to your needs.

2. Where can I buy 1,2,4-Triazole in India?
You can purchase 1,2,4-Triazole from MULTICHEM, a leading importer with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments across India. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for 1,2,4-Triazole?
Our minimum order quantity (MOQ) for 1,2,4-Triazole is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 250kg

. 4. How can I ensure the quality of 1,2,4-Triazole supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.